Products related to Biomarkers:
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Biomarkers in Inflammatory Bowel Diseases
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner.The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice.The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
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Handbook of Biomarkers and Precision Medicine
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches.By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of HealthHandbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine.A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments.The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine.They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia.Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK.Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK.Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
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Leong's Manual of Diagnostic Biomarkers for Immunohistology
With the interest in biomarkers available for diagnostic, therapeutic, prognostic and research applications growing rapidly, it is now expected that every pathologist should be aware of the correct application of immunohistochemistry in daily practice.This fully updated fourth edition provides practical guidance about preparation, key uses and pitfalls of antibodies for immunohistology in a unique A-Z format.Seventeen full colour infographics present detail about specific biomarkers, including FOXL2, GATA3 and SOX10, pulling out information about expression in tissues and prognosis.Expanded with new biomarkers and the removal of biomarkers that are no longer in common use, each entry in this concise new edition follows a standard structure for quick and easy access by busy readers.
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Salivary Biomarkers for Oral and Systemic Diseases
Salivary Biomarkers for Oral and Systemic Diseases contains contributions from a number of experts and highly regarded scientists and clinicians.This book offers unique insights into the science of biomarkers in oral diseases and how to use biomarkers to help in the diagnosis of both oral and systemic diseases.The book focuses on all oral fluids, such as GCF, peri-implant fluid, and whole mouth saliva, and outlines the practical importance of the use of other biological samples from the oral cavity.This is a must-have reference for all those interested in salivary biomarkers across the bioscience and biomedical fields.
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Where has photonics gone?
Photonics has advanced and expanded into various industries and applications, including telecommunications, healthcare, manufacturing, and defense. It has enabled the development of faster and more efficient communication systems, medical imaging technologies, high-precision manufacturing tools, and advanced military equipment. Photonics has also made significant contributions to renewable energy technologies, such as solar cells and LED lighting. Overall, photonics has become an integral part of modern technology and continues to drive innovation in a wide range of fields.
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How advanced is nanotechnology?
Nanotechnology is a rapidly advancing field that involves manipulating materials at the nanoscale, which is on the order of billionths of a meter. It has already led to significant advancements in various industries, including medicine, electronics, and materials science. Researchers are continually developing new techniques and applications for nanotechnology, such as targeted drug delivery, nanoelectronics, and nanomaterials with unique properties. While nanotechnology is still in its early stages, it holds great promise for revolutionizing many aspects of our lives in the future.
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What is NMR spectroscopy?
Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique used to study the structure and dynamics of molecules. It provides detailed information about the chemical environment, connectivity, and conformation of atoms within a molecule. By measuring the interactions of atomic nuclei with a magnetic field, NMR spectroscopy can elucidate the molecular structure of organic compounds, proteins, and other biomolecules. This technique is widely used in chemistry, biochemistry, and structural biology for research and drug discovery purposes.
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How is spectroscopy applied?
Spectroscopy is applied in various fields such as chemistry, physics, astronomy, and environmental science. In chemistry, it is used to identify and analyze the chemical composition of substances. In physics, it is used to study the interaction of electromagnetic radiation with matter. In astronomy, it is used to determine the composition, temperature, and motion of celestial objects. In environmental science, it is used to monitor air and water quality by analyzing the presence of pollutants. Overall, spectroscopy is a versatile tool for analyzing the properties of different materials and substances.
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Raman Scattering on Emerging Semiconductors and Oxides
Raman Scattering on Emerging Semiconductors and Oxides presents Raman scattering studies.It describes the key fundamental elements in applying Raman spectroscopies to various semiconductors and oxides without complicated and deep Raman theories. Across nine chapters, it covers:• SiC and IV-IV semiconductors,• III-GaN and nitride semiconductors,• III-V and II-VI semiconductors,• ZnO-based and GaO-based semiconducting oxides,• Graphene, ferroelectric oxides, and other emerging materials,• Wide-bandgap semiconductors of SiC, GaN, and ZnO, and• Ultra-wide gap semiconductors of AlN, Ga2O3, and graphene. Key achievements from the author and collaborators in the above fields are referred to and cited with typical Raman spectral graphs and analyses.Written for engineers, scientists, and academics, this comprehensive book will be fundamental for newcomers in Raman spectroscopy. Zhe Chuan Feng has had an impressive career spanning many years of important work in engineering and tech, including as a professor at the Graduate Institute of Photonics & Optoelectronics and Department of Electrical Engineering, National Taiwan University, Taipei; establishing the Science Exploring Lab; joining Kennesaw State University as an adjunct professor, part-time; and at the Department of Electrical and Computer Engineering, Southern Polytechnic College of Engineering and Engineering Technology.Currently, he is focusing on materials research for LED, III-nitrides, SiC, ZnO, other semiconductors/oxides, and nanostructures and has devoted time to materials research and growth of III-V and II-VI compounds, LED, III nitrides, SiC, ZnO, GaO, and other semiconductors/oxides. Professor Feng has also edited and published multiple review books in his field, alongside authoring scientific journal papers and conference/proceeding papers.He has organized symposiums and been an invited speaker at different international conferences and universities.He has also served as a guest editor for special journal issues.
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Exosomes in Cardiovascular Diseases : Biomarkers, Pathological and Therapeutic Effects
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects.It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well.Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized.Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy.Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted.Finally, future prospects of exosomes in cardiovascular research would be provided.This is an essential reference for researchers working in cell biology and regeneration, as well as clinicianssuch as cardiologist.
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Applied Raman Spectroscopy : Concepts, Instrumentation, Chemometrics, and Life Science Applications
Applied Raman Spectroscopy: Concepts, Instrumentation, Chemometrics, and Life Science Applications synthesizes recent developments in the field, providing an updated overview.The book focuses on the modern concepts of Raman spectroscopy techniques, recent technological innovations, data analysis using chemometric methods, along with the latest examples of life science applications relevant in academia and industries.It will be beneficial to researchers from various branches of science and technology, and it will point them to modern techniques coupled with data analysis methods.In addition, it will help instruct new readers on Raman spectroscopy and hyphenated Raman spectroscopic techniques. The book is primarily written for analytical and physical chemistry students and researchers at a more advanced level who require a broad introductory overview of the applications of Raman spectroscopy, as well as those working in applied industry and clinical laboratories.Students, researchers, and industry workers in related fields, including X-ray and materials science, agriculture, botany, molecular biology and biotechnology, mineralogy, and environmental science will also find it very useful.
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Drug Development for Gene Therapy : Translational Biomarkers, Bioanalysis, and Companion Diagnostics
Drug Development for Gene Therapy Industry-centric perspective on translational and bioanalytical challenges and best practices for gene therapies Drug Development for Gene Therapy focuses on the translational and bioanalytical challenges and best practices for gene therapy modalities, presenting a significant body of data, including information related to safety and efficacy, necessary to advance through the development pipeline into clinical use.The text covers bioanalytical methods and platforms including patient screening assays, different PCR tests, enzyme activity assays, ELISpot, NGS, LC/MS, and immunoassays, with FDA and EMA guidelines on gene therapy safety and efficacy, along with companion diagnostics regulations from US and EU perspectives.The chapters offer an in-depth discussion of the basics and best practices for translational biomarkers, bioanalysis, and developing companion diagnostics / lab tests for gene therapies in the pharma and biopharma industries.To aid in reader comprehension, the text includes clinical examples of relevant therapies in related chapters.Some of the core topics covered include study design, immunogenicity, various bioanalytical methods and their applications, and global regulatory issues.Written by two highly qualified authors with significant experience in the field, Drug Development for Gene Therapy includes information on: Bioanalytical methods to detect pre-existing antibodies against adeno-associated viruses (AAV) capsidsDetection of cellular immunity and humoral response to viral capsids and transgene proteins, and immunogenicity of gene therapy productsNonclinical and clinical study considerations and methods for biodistribution and sheddingQuantification of transgene protein expression and biochemical function, and substrate and distal pharmacodynamic biomarker measurements for gene therapyDetection and quantification of rAAV integration and off-target editingCurrent regulatory landscape for gene therapy product development and the role of biomarkers and general regulatory considerations for gene therapy companion diagnostics With comprehensive coverage of the subject, Drug Development for Gene Therapy is a must-have resource for researchers and developers in the areas of pharmaceuticals, biopharmaceuticals, and contract research organizations (CROs), along with professors, researchers, and advanced students in chemistry, biological, biomedical engineering, pharmaceuticals, and medical sciences.
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Is it possible to create new materials through lower dimensional levels by using femtotechnology instead of nanotechnology?
Femtotechnology operates at the scale of femtometers (10^-15 meters), which is smaller than the scale of nanotechnology (10^-9 meters). At this scale, it is theoretically possible to manipulate individual atomic nuclei and electrons to create entirely new materials with unique properties. By harnessing the power of femtotechnology, scientists may be able to engineer materials with unprecedented strength, conductivity, and other desirable characteristics. However, femtotechnology is still largely theoretical and has not yet been realized in practical applications, so its potential for creating new materials through lower dimensional levels remains speculative.
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Why is Rutherford's scattering experiment called a scattering experiment at all?
Rutherford's experiment is called a scattering experiment because it involved firing alpha particles at a thin gold foil and observing how they scattered after hitting the foil. The term "scattering" refers to the process of particles being deflected from their original path as a result of collisions with the atoms in the foil. By analyzing the pattern of scattering, Rutherford was able to deduce the structure of the atom and propose the existence of a dense, positively charged nucleus at its center. This experiment was crucial in advancing our understanding of atomic structure and the behavior of subatomic particles.
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What are the arguments against nanotechnology?
Some arguments against nanotechnology include concerns about potential health and environmental risks, such as the unknown effects of nanoparticles on living organisms and ecosystems. There are also ethical concerns related to the potential misuse of nanotechnology for military purposes or surveillance. Additionally, there are worries about the unequal distribution of benefits and risks, with some groups potentially being disproportionately affected by the consequences of nanotechnology development.
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What are the dangers of nanotechnology?
The dangers of nanotechnology include potential environmental and health risks. Nanoparticles are so small that they can easily enter the body through inhalation, ingestion, or skin contact, potentially causing harm to human health. There is also concern about the potential for nanoparticles to accumulate in the environment and impact ecosystems. Additionally, the long-term effects of exposure to nanoparticles are not fully understood, raising concerns about their safety. Therefore, it is important to carefully consider the potential risks and benefits of nanotechnology and to regulate its use to minimize potential dangers.
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